Titanium foam was prepared by space holder sintering process under different particle diameter, volume ratio and sintering temperature and time. The pore structure of titanium foam was analyzed by optical metallography and scanning electron microscope. The mechanical properties of titanium foam were evaluated by compression test at room temperature. The results show that the pore of titanium foam is round on the cross-section and is elliptical on the longitudinal section. The difference between the porosity of titanium foam and the volume ratio of space holder increases with the increase of the particle diameter, volume ratio, sintering temperature and time. At the same time, the higher the sintering temperature, the denser the pore wall of titanium foam is. Unlike the traditional foam materials, there is no obvious stress platform in the relationship between the stress and strain of titanium foam. The compressive strength and elastic modulus decrease with the increase of porosity. When the porosity is 67.6%, the compressive strength and elastic modulus reach 14.4MPa and 1.17GPa respectively. The compressive strength increases first and then decreases with the increase of pore diameter, while the elastic modulus remains unchanged. When the pore diameter reaches 1.15-1.53 mm, the compressive strength and elastic modulus reach 48.9 MPa and 1.72 GPa respectively.