To evaluate the effect of CeO2 on the microstructure and property of SiO2-Al2O3-MgO-Na2O-K2O-F system, 2wt%, 3wt%, 4wt%, 5wt% CeO2 were added respectively. Crystallization behaviors, crystalline phases, microstructures of the glass-ceramics with various compositions were investigated by differential thermal analysis (DTA), X-ray diffraction (XRD) and scanning electron micro scope (SEM) analysis. Three-point bending strength, micro hardness, machinability and wear abrationlosing weight were also measured. The results revealed that the main crystalline phase of glass ceramics wasn’t changed, but the aspect ratio of mica crystals increased upon adding CeO2 With increasing of the CeO2 content, the three-point bending strength firstly increased and then decreased, microhardness firstly decreased and then increased, wear resistance decreased and machinability increased obviously. The addition of 3% CeO2 enhanced bending strength of SiO2-Al2O3-MgO-Na2O-K2O-F glass-ceramics at the same time could give appropriate color similar to teeth. The excessive addition would be unbeneficial to improving of bending strength and wear resistance