The multi-objective optimization was studied using response surface method (RSM) and FEM simulation for a preform design of aeroengine disk forging. Firstly, taking the deformation homogeneity within forgings and die filling completeness as the objective, a reduced quadratic model was developed through regression analysis and ANOVA (analysis of variance), and then the optimal results are obtained and discussed. Secondly, redesign and optimization were carried out to reduce the deformation load on the basis of the former optimization results. The results show that RSM is an effective and flexible method to realize multi-objective preform optimization design for hard deformed material forging.