In order to improve the leaching efficiency of vanadium pentoxide from BOF slag containing low-vanadium oxide and provide theoretical foundations, the whole leaching process was analyzed from the kinetic aspect. The effects of reaction temperature, the liquid-solid ratio, sulphuric acid concentration and stirring speed on the leaching efficiency were investigated. The results show that the leaching rate of vanadium pentoxide can reach 95.3% under the condition of temperature 90 oC, liquid-solid ratio 10: 1, sulfuric acid concentration 6 mol/L, and leaching time 9 h. By means of the orthogonal experiment and kinetic deduction, an empirical equation for the leaching process is established, and the apparent activation energy is 12.794 kJ/mol. The leaching process of BOF slag containing low-vanadium oxide could be simulated with a shrinking core model, which indicates that the control factor of the leaching process is the diffusion rate of reacting reagents in a porous solid layer. The leaching efficiency and speed can be increased by enhancing the temperature, liquid-solid ratio and sulfuric acid concentration