The Mo-Ru-Se nano-clusters doped with Pt were synthesized by a low temperature method and characterized by XRD, EDS and XPS. The electro-catalytic performance to oxygen reduction was studied for the Pt-W-Ru-Se catalysts in acid electrolytes with or without methanol by a linear sweep voltammetry (LSV) method. The results show that the activity of W-Ru-Se doped with Pt on oxygen reduction is markedly increased compared with that of platinum-free W-Ru-Se under the same reaction condition. The optimum Pt loading is about 5 %. In 0.5 mol?L-1 H2SO4, the initial potential of oxygen reduction of Pt-W-Ru-Se (5% Pt) is 0.25 V, the peak current density is 310 mA·mg-1, approaching 2.2 times that of W-Ru-Se and the activity is close to that of Pt/C. In addition, the activity and methanol-resistance of Pt-W-Ru-Se (5% Pt) is better than that of Pt/C in 0.5 mol?L-1 H2SO4 with methanol