In the present research, W particles were coated using Ni electroless plating technique, and the Ni coated W powders were mixed uniformly with copper powders. 65W-25Cu-10Ni alloy with low W-W contiguity was successfully prepared by SPS method using the composite powders, and the quasistatic mechanical properties were studied. The results show that, after the Ni electroless plating process, Ni is uniformly distributed on the surface of W particles, and the integrating force is strong. The 65W-25Cu-10Ni alloy prepared by SPS method is uniform and dense in microstructure. Compared with 65W-35Cu alloy, 65W-25Cu-10Ni alloy exhibits higher strength and better ductility under quasistatic compression condition, and exhibits higher strength under quasistatic tensile condition, but the ductility under quasistatic tensile condition is not obviously improved. The analysis of the failure mechanism shows that, compared with 65W-35Cu alloy, W-W contiguity is evidently decreased in the 65W-25Cu-10Ni alloy, the matrix is replaced by Cu0.81Ni0.19 solid solution, and metallurgical bonding is formed between W and the matrix, all these above are benefit to increase the strength of 65W-25Cu-10Ni alloy. Meanwhile, the decrease of W-W contiguity and the increase of the interfacial strength are account for ductility increase of 65W-25Cu-10Ni alloy under quasistatic compression condition.