Titanium have been widely used in aerospace and other fields . But one of the key factors leading to low processing efficiency is the sticking problem between titanium plate and the roll surface during the process of cold rolling. Focusing on this problem, the interfacial adhesion energies between Ti, Al, Cu, Mg and Fe and their internal binding energies were calculated. It is found that the interfacial adhesion energy between Ti and Fe is not only greater than the internal binding energy of Ti, but also greater than the internal binding energy of Fe, which is different from the other three metals. Therefore, fracture will occur on the deeper layer of Titanium plate’s substrate with close contact and relative movement between Fe and Ti surfaces. Then, the sticking situation of TA2 cold-rolling is analyzed. It is found that lubricating film is easier to rupture than other metals due to titanium’s unique properties,, which results in direct contact and sticking between roller and Titanium plate. Consequently, the sticking index is proposed to characterize the degree of sticking, the impact of draft rolling schedule, rolling speed, lubricant type on the degree of sticking is analyzed. It is concluded that the cold-rolling speed of TA2 should be lower than 3m/s, the reduction rate of each pass should be less than 20%, which is important to guide the productive practice and prevent sticking.