Compression tests were done at temperature ranging from 250 to 450℃,strain-rate from 0.005 to 5 s-1. The rolling test, numerical simulation and damage analysis were conducted. The thermal processing diagram was calculated by the method of dynamic material model . The material flow stress model was established by parameter method of Zener-Hollomon. Combined with the principle of heat transfer and rolling theory, the rheological stress model of hot rolling process was established. The results showed that: The model in reasonable temperature range to solve, effectively improve the prediction accuracy. The main heat transfer mechanism in forward slip area and backward slip area was different and the rolling force was mainly distributed in backward slip area, this area was the key research area of edge crack. In the rolling process, Normalized C-L damage value was maximum on sheet edge. The lower the deformation temperature and the more pass reduction, the greater the value of damage, which was consistent with the outcome of the rolling experiment. Under different rolling conditions, the results of the model solution were consistent with the numerical simulation of hot rolling process.