The effects of process parameters on macro-morphology, microstructure, mechanical properties of the joints, which were frabricated by friction stir welding (FSW) using 3mm 2A14 aluminium alloy and TC4 titanium alloy with a 0.05mm Zn ribbon as intermediate layer, were studied. The results indicate that the well-formed joints can fabricated by friction stir welding with the parameters that welding velocity is 75 mm/min, rotation speed is 375~950 r/min and offset between the center of pin and interface of two plate is 2.5mm. The surface roughness reduces with increase of rotatation speed and then increases, while the tensile strength of joints decrease gradually as the increase of rotation speed. However, as increase of welding velocity, the surface roughness increases, and the tesile strength decreases. When the welding velocity, rotation speed and offset are 75mm/min, 375 r/min and 2.5mm, respectively, the maximum tensile strength exceed to 237.3 MPa, nearly 57.7% of the alluminum alloy.