The hot compression tests for TA15 Titanium alloy were conducted at 0.001s-1~1s-1 strain rates and 750℃~ 1050℃temperatures.The effect of deformation temperature and strain rate on the flow stress was analyzed. According to the test results, the rise temperature on the deformation process was calculated, which is proportional to strain rate and strain. The maximum temperature rise 122.63℃ is produced In the low temperature and high strain rate of .Finally, considering the thermal effect leads to deformation temperature, based on Sellars-Tegart constitutive model, the constitutive model is established for the microstructure evolution of TA15 titanium alloy at hot deformation.