The effects of process parameters, microstructure, mechanical properties of the joints, which were frabricated by friction stir welding (FSW) using 3mm 2A14 aluminium alloy and TC4 titanium alloy with a 0.05mm Zn and Ni ribbon as intermediate layer, were studied. The results indicate that the joint maximum tensile strength exceed to 237.3 MPa when the welding velocity, rotation speed are 75mm/min, 375 r/min, respectively, nearly 56.7% of the alluminum alloy. The joint maximum tensile strength reached 285.3 MPa at the same process parameters with add Zn as intermediate layer, nearly 68% of the alluminum alloy when add Ni as intermediate layer what can inhibit brittle phase TiAl₃ , which the fracture mode is brittle/ductile fracture.