Wear behavior and characteristic of TC4 alloy in TC4/GCr15 and TC4/ W6Mo5Cr4V2 tribo-systems were studied. The morphologies, element and structure of worn surface and cross-section were observed and analysed with SEM, EDS and XRD. The results show that in two tribo-systems, wear rate of titanium alloy at 25℃ was high and wear performance was poor; at 400℃, wear rate in TC4/ W6Mo5Cr4V2 was much higher than that in TC4/GCr15; wear rate of titanium alloy at 600℃ was very low and wear rate in TC4/GCr15 was lower than that in TC4/ W6Mo5Cr4V2.At 400 and 600℃, counterface materials have different impact on wear rate of alloy. The decrease of wear rate was related with the amount of oxides, titanium alloy presented extremely low wear rate and excellent wear performance when worn surface contained a large amount of oxides which can be existed stably.