In order to obtain the optimal heat treatment condition of explosive-welded zirconium-titanium-steel clad plate, the effects of holding temperature, holding time and rate of temperature on bonding strength and residual stress of clad plate were studied by orthogonal test method. The investigation results show that the clad plate can obtain the best combination of bonding strength and residual stress under holding temperature of 540℃, holding time of 1h and rate of temperature of 60℃/h. If the holding temperature is too higher or the holding time is too longer, the bonding strength of explosive-welded zirconium-titanium-steel clad plate will decrease. Besides, the microhardness, the microstructures and the fracture morphology of bonding interface were measured and observed under the optimal heat treatment condition. The analysis shows that the fine grain zone is formed near the bonding interface and its microhardness is higher. The fracture appearance of bonding test is a mixture of ductile and cleavage fracture.