For improvement of the safety and compatibility of nuclear engineering systems, Uranium intermetallic compounds are of technological importance for nuclear fuel chemistry and physics, since these compounds are occasionally found to exist as metallic inclusions in irradiated fuel. The predictions of compatibility of metallic uranium with stainless steel, Cu and Al cladding may require the characteristics of the intermetallics. It is therefore useful to understand the physico-chemical properties of the uranium intermetallic compounds. In the present study, UCu, UAl and UFe have been selected as the intermetallic compounds through method of materials genome engineering, the microstructure, phase transformation and mechanical properties such as elastic moduli and hardness of the compounds have been studied by means of nanoindentation, XRD, SEM, EDX. The microstructure of the compounds displayed a new phase with more than 10 μm thickness, which has a ration of U:Cu with 1:4. The nanoindentation testing on sample indicated that hardness of Uranium intermetallic compounds are higher than that of metal U and Cu. Uranium intermetallic compounds has a Young’s moduli with 121GPa,and a thermal expand coefficient with the value of 7.3×10_-5K_-1.