Based on Ti-Al-M alloys , the effect of V、Mo elements on as-cast microstructure as well as the microstructure of different heat treatment processings is studied. V、Mo elements can change the solidification path of conventional γ- TiAl, avoid peritectic reaction, and preserve β phase to room temperature. The martensite mode will be observed in the microstructure subjected to water quenching condition, with increasing the content of V、Mo elements. During two-step heat treatment procedure, with Mo addition, alloys are prone to the transformation reaction of α→β＋γ as well as β→β＋γ.