The influence of Ni-Al interatomic potential from the first-nearest neighbor to the fourth-nearest neighbor on the precipitation process of L1₀ pre-precipitation phase in Ni₇₅Al₁₄Cr₁₁ alloy was investigated by the Microscopic Phase-Field method. As the third-nearest Ni-Al interatomic potential increases or the fourth-nearest interatomic potential decreases, L1₀ pre-precipitation phase and L1₂ phase appears in advance; besides, the volume fraction of L1₀ pre-precipitated phase decreases while the final volume fraction of L1₂ phase almost remains unchanged. Whereas the opposite, L1₀ pre-precipitation phase and L1₂ phase appears later; besides, the volume fraction of both phases increases. Compared with the above two, the first-nearest interatomic potential has the less impact and the second-nearest Ni-Al interatomic potential has the least impact on the precipitation process of L1₀ pre-precipitation phase and L1₂ phase. Further research shows that Ni-Al interatomic potential does not affect the precipitation mechanism of the alloy and will affect the precipitation time, speed, volume fraction and precipitation morphology of L1₀ pre-precipitation phase and L1₂ equilibrium phase, thus affecting the structure and properties of Ni₇₅Al₁₄Cr₁₁ superalloy, which has guiding significance for alloy optimization design.