The effect of the content of TiO2 in CaF2-CaO-Al2O3-MgO-Li2O-(TiO2) slag on the content of Al and Ti in Incoloy 825 alloy was discussed by the high temperature slag-metal equilibrium experiment. The relationship between the activity of TiO2 and Al2O3 in slag and the compositions of slag was analyzed by FactSage 7.3 thermodynamic software. The influence rule of components in slag on Gibbs free energy of reaction 4[Al]+3(TiO2) = 3[Ti]+2(Al2O3) and the content of equilibrium Al and Ti in alloy were studied. The results show that the Gibbs free energy of the reaction is negatively correlated with TiO2, CaF2 and MgO in the slag, and positively correlated with CaO and Al2O3. When the content of TiO2 in slag is 0-7.27%, the effect of burning Ti to increase Al is gradually reduced. When the content of TiO2 is 11.27%, the effect of burning Al to increase Ti is appeared. At the same temperature, with the increase of CaO and Al2O3 content in slag, the equilibrium Ti content in alloy decreases and the equilibrium Al content increases. With the increase of TiO2 content in slag, the equilibrium Ti content in alloy increases and the equilibrium Al content decreases. The change of CaF2 and MgO content in slag has little effect on the equilibrium Al and Ti content in the alloy. The experimental results are in good agreement with the thermodynamic calculation results.