In this paper, the as-cast microstructure of Ti-15Mo alloy with high oxygen content and the microstructure and corresponding properties obtained by solution treatment at different temperatures are studied. Composition analysis shows that 0.8wt% O is dissolved in the alloy, hereinafter referred to as Ti-15Mo-0.8O alloy. The microstructure transformation of Ti-15Mo-0.8O alloy was observed and analyzed by optical microscope (OM), scanning electron microscope (SEM) and X-ray diffraction (XRD). The results show that the as-cast structure of the alloy consists of α and β phases. After solid solution treatment at 900℃, 1000℃, 1100℃/2h, the phase composition transformation process of the alloy is α+β+TOβ+TOβ; The lattice constant of β phase of alloy gradually increases with the increase of solid solution temperature. Hardness and room temperature compression tests were carried out by Vickers hardness tester and universal testing machine. The results show that the highest hardness of the sample after solution treatment at 1100℃/2h is 455HV20；The sample after solution treatment at 1100℃/2h has the best compression performance, with compressive yield strength of 1617Mpa and compressive strength of 2308Mpa respectively, and compression ratio of 22%.