The high-temperature self-lubricating CoCrNi-(3.0 wt.%, 5.0 wt.%, 7.0 wt.%) MoS2 coatings were prepared on the surface of GH4169 alloy by using a powder metallurgy technology (P/M). The high-temperature tribological properties of coatings sliding against Si3N4 ceramic ball were investigated by using a ball-on-disk high-temperature tribo-meter. The effect of testing temperature, sliding speed and applied load on the tribological properties of coatings was systematically studied from 20 °C to 800 °C. The phase and microstructure of the coatings were analyzed by X-ray diffractometer and scanning electron microscope, and the bonding strength of coating and substracte was tested through the thermal shock test. The results showed that the MoS2 formed Mo2S3 and CrxSy phases with other metal elements. The coatings had a good interface structure with the substrate. The coatings consisted of γ(fcc), ε(hcp), CrxNiy and solid lubricating phases (Mo2S3, CrxSy). At low temperature, the friction coefficient of coatings gradually decreased with the increase of MoS2. At high temperature, the coatings had an excellent high-temperature tribological properties. It was ascribed to the synergistic effect of chromate, oxide and sulfide on the worn surface. The wear rate of the coatings was below 5.5×10-5 mm3N-1m-1 over a wide temperature range, and the wear resistance of the coatings was 4~17 times higher than that of the substrate from 20 °C to 600 °C. The CoCrNi matrix coating with 5.0 wt.% MoS2 showed the best high-temperature tribological properties.