In this paper, based on theoretical and simulation analysis, the 6061 Al / AZ31B Mg / 6061 Al laminated plates were fabricated by hot rolling, and the microstructure and mechanical properties were investigated in detail. The best coverage rate of 6061Al of the laminated plate was obtained by classical laminated plate theory and the optimal reduction rate of the laminated plate was obtained by Finite Element Method (FEM). According to the theoretical and simulation results, the rolling experiments of 6061 Al / AZ31B Mg / 6061 Al laminated plate were carried out with different rolling temperatures, reduction rates and annealing time. And the microstructure experiment, tensile property test and energy spectrum analysis of the laminated plates were carried out. The results showed that refined grains were discovered in the Mg layer at the interface, and the formation of an intermetallic compound layer consisting of Mg17Al12 and Mg2Al3 was identified at the interface. For the mechanical properties, with the increase of rolling reduction rate, the tensile strength, elongation and interface diffusion thickness of the 6061 Al / AZ31B Mg / 6061 Al laminated plate increased significantly; with the increase of rolling temperature, the tensile strength, elongation and interface diffusion thickness of the laminated plate decreased greatly; with the increase of annealing time, the tensile strength decreased and interface diffusion thickness of the laminated plate increased.