Cast nickel-base superalloy are widely used in hot end components such as turbine blades of aeroengines because of its excellent high temperature performance. Aeroengine turbine blade is one of the parts with the worst working environment and the most complicated structure. The structure of aeroengine turbine blade is very complex and its working environment is also very bad. The alloy bears serious stress and strain cycle damage nnder the action of high temperature alternating stress produced during engine operation. And cracks often initiation and further development in these weak areas, resulting in low cycle fatigue failure of the alloy, which seriously affects the service life of the alloy. Therefore, the research on the fatigue performance of the alloy is particularly important. In this paper, four factors affecting the low cycle fatigue properties of cast nickel-base superalloy are described in detail, including surface defects, internal structure and defects, crystal orientation and test conditions. Based on the characteristics of dislocation movement mode and morphology, the deformation mechanism of cast nickel-base superalloy at different temperatures is studied. Finally, the prediction methods of low cycle fatigue life are summarized.