In this paper, a CrMn0.3FeVCu0.06 high entropy alloy was prepared by powder metallurgy technology. X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed to characterize the phase formation and microstructure of the milled powders and sintered bulk CrMn0.3FeVCu0.06 HEA. It was found that the sintered bulk CrMn0.3FeVCu0.06 high-entropy alloy exhibits a dual-phase structure of BCC structured matrix and FCC particles. The bulk CrMnFeVTi HEA exhibits high values of compressive strength and ductility due to grain boundary strengthening and precipitate strengthening. In addition, effects of fluence and temperature on surface morphology and mechanical properties of the CrMn0.3FeVCu0.06 alloy, irradiated by low energy high flux deuterium(D) plasma beams, were systematically investigated. When irradiation conditions were set as 500 K, 40 eV and 1×1022 m-2s-1, the critical fluence for blistering in the CrMn0.3FeVCu0.06 alloy is higher than 2.0×1025 m-2, which is much larger than the critical fluence in polycrystalline tungsten with similar irradiation conditions. It can been seen that the CrMn0.3FeVCu0.06 alloy has better irradiation resistance than polycrystalline tungsten in terms of D retention or inhibiting blister formation. The hardness of the alloy gradually increases with the increase of deuterium fluence, but decreases with increasing irradiation temperature. Due to severe lattice-distortion and sluggish diffusion effects HEA, the irradiation hardening in CrMn0.3FeVCu0.06 HEA is more sensitive to the change of irradiation temperature.