In this paper, Zn-0.75Cu-0.15Ti-0.3Mg alloy sheet was prepared by extrusion and rolling method, and its microstructure evolution process, mechanical properties and corrosion resistance were discussed. The results show that the Zn-0.75Cu-0.15Ti-0.3Mg alloy exhibits a fine equiaxed crystal morphology after extrusion deformation. Micro-scale TiZn3 and MgCuZn phases and nano-scale CuZn5 phase exist in Zn matrix. Rolling deformation promotes the grain growth of Zn matrix and the grain size is relatively non-uniform. With the increase of rolling deformation, the matrix deformation induces the precipitation of more MgCuZn in the Zn grains. After rolling deformation, both the strength and elongation of the alloy show a decreasing trend, and the tensile strength decreases from 142.7 MPa to less than 110 MPa, which was mainly attributed to the growth of grains and the increase of brittle second phases. However, the rolling deformation contributes to the improvement of the corrosion resistance of the alloy. The as-rolled alloy exhibits a lower corrosion current density (25.47×10-5Amp/cm2) and a higher corrosion product layer resistance (166.7Ω/cm2) compared to extruded alloy.