The thermal compression test of TC6 titanium alloy under low strain rate and large deformation was carried out by Thermecmastor Z100kn thermal simulation machine. The true stress-strain curves were obtained when the deformation temperature was 900 ~ 945℃, the strain rate was 0.0001 ~ 0.1s-1 and the deformation degree was 70%.The traditional friction correction model and the improved friction correction model were used to correct the true stress-strain curve, and the strain-compensated Arrhenius model based on the friction correction was established. The results show that the modified friction correction model can better characterize the true stress-strain dynamic response of materials under large deformation. The strain-compensated Arrhenius model modified by friction model has higher linear correlation, smaller mean absolute error and higher prediction accuracy.