High-entropy alloys based on the multiple components design concept exhibit excellent comprehensive properties such as high strength, high toughness, good wear resistance, oxidation resistance and thermal stability, making it prospective to become an excellent new structural material. As for the composition design, high-entropy alloys can adjust its stacking fault energy and microstructure by changing the concentration of each principal element, doping interstitial atoms and so on, and then introduce multiple strengthening and toughening mechanisms such as precipitation strengthening, fine grain strengthening, phase transformation or twinning-induced plasticity effect, thereby improving its comprehensive mechanical properties. In this paper, the effects of composition design with non-equiatomic and interstitial C/N atom additions on the microstructure, mechanical properties and deformation mechanism of face-centered cubic high-entropy alloys are summarized, so as to provide the theoretical basis for the design of the new high-performance face-centered cubic high entropy alloys.