The corrosive lubricanting environments that TC4 alloy being exposed can result in severe corrosion wear. Corrosion wear experiments were carried out to explore the corrosion and wear mechanisms of TC4 alloy, as well as the synergistic between corrosion and wear. In this experiment, distilled water, artificial acid rain, and artificial seawater were selected as corrosive lubricating media for the GCr15/TC4 friction counterpart. The Anton Paar TRB₃ tester were used for the experiments. The results suggest that the wear mechanisms of TC4 alloy in three water-based media are significantly different. Adhesive wear is most pronounced in distilled water, as well as fatigue delamination dominates in artificial seawater, however, abrasive wear is most significant in acid rain. The wear length, width, depth and volume of the wear profiles in acid rain are greater than those in artificial seawater and distilled water. The wear volume of TC4 alloy in artificial acid rain is larger than that in artificial seawater and distilled water, and it increased linearly with the number of cycles and normal loads. It shows that GCr15/TC4 is the most sensitive to acid rain, as well as suffers the most serious damage. In these three media, the synergistic factor of TC4 corrosion and wear in descending order is artificial acid rain, artificial seawater, and distilled water. The wear loss of TC4 alloy in distilled water is dominated by mechanical factors, while in artificial seawater and acid rain is dominated by corrosion-wear interaction and mechanical factors. The synergistic factor decreases as the load increases, and the influence of mechanical factors on corrosion wear becomes more significant.