The wear resistance and tensile property of two low-cost, easy-to-deform Ti-44Al-3Mn-0.8Mo (TMM) and Ti-44Al-3Mn-0.4Mo-0.4W(TMMW) alloys (atomic fraction, %, the same below) were comparatively tested. The effects of replacing 0.8 Mo with 0.4Mo-0.4W on their wear resistance, microhardness, tensile property and microstructure were analyzed. The results show that replacing part of Mo with W can obviously improve the wear resistance and microhardness of Ti-Al-Mn-Mo alloy, and also increase the tensile strength of the alloy at room temperature and high temperature. The room temperature elongation is increased from 0.75% to 1.50%, while the high temperature elongation is slightly reduced. It is found that the β-stabilizing effect of W in the alloys is slightly weaker than that of Mo, and the replacement of W reduces the content of β_o phase and γ phase remaining in the structure, increases the content of α₂ phase obviously, increases the content of lamellar structure, and decreases the lamellar spacing. The higher microhardness and better wear resistance of TMMW alloy are closely related to the changes of microstructure and phase composition. The decrease in β_o phase content, the increase in lamellar content and the decrease in lamellar thickness are the main reasons for the higher tensile strength and better room temperature elongation of the alloy after W replaces part of Mo.