FeCrAlCu, FeCrAlCuNi, FeCrAlCuCo, and FeCrAlCuNiCo high-entropy alloy (HEA) coatings were synthesized on the surface of 45# steel through cold spraying-assisted laser remelting. Results reveal that all four HEA coatings are composed of face-centered cubic+body-centered cubic phases. Additionally, the microstructure of the coatings consists of columnar dendrites. With the simultaneous addition of both Ni and Co elements, the columnar dendritic grains are gradually refined in the coating. Moreover, the FeCrAlCuNiCo HEA coating exhibits excellent friction performance with the coating hardness of 5847.7 MPa, friction factor of 0.45, and wear rate of 3.72×10^-5 mm³·N^-1·m^-1. The predominant wear mechanism is the adhesive wear and abrasive wear.