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钛基植入材料的物理抗菌表面修饰
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湖南大学 生物学院,湖南 长沙 410082

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基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


Physical Antibacterial Surface Modifications on Titanium-Based Implant Materials
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College of Biology, Hunan University, Changsha 410082, China

Fund Project:

National Natural Science Foundation of China (52171114)

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    摘要:

    钛基植入体的感染是其临床应用的重要挑战,特别是当植入体表面形成了生物膜之后。抗生素、金属纳米颗粒和抗菌肽等抗菌药物已经广泛用于治疗钛植入体的感染。然而,这些化学手段具有潜在的毒性、抗生素抗药性以及长效抗菌效果不足等缺点。因此,钛基植入体的物理抗菌表面正吸引着越来越多的关注。概述了不同的钛基生物材料表面仅依靠植入体本身的物理性质(如纳米拓扑结构)或外源性物理刺激(如光催化)对各种细菌的抗菌效果。影响物理抗菌过程的因素有很多,包括纳米拓扑结构的尺寸、形貌和密度以及细菌生长周期等。此外,对钛基植入材料不同物理抗菌表面的机理进行了总结。

    Abstract:

    Infections associated with titanium (Ti)-based implants present significant challenges in clinical treatments, especially when biofilms already form on the implant surface. Many antimicrobial agents, including antibiotics, metallic nanoparticles and antimicrobial peptides, have been extensively used to deal with Ti implant infections. However, these chemical approaches suffer from potential toxicity, antibiotic resistance and poor long-term antibacterial performance. Hence, physical antibacterial surfaces on Ti-based implants have attracted increasing attention. The antibacterial behavior of different surfaces on Ti-based biomaterials against various bacteria only by physical properties of the implants themselves (e.g., nanotopography) or exogenous physical stimulus (e.g., photocatalysis) was reviewed, as well as parameters influencing the physical antibacterial processes, such as size, shape and density of the surface nanotextures, and bacterial growth phases. Besides, mechanisms of different fabrication techniques for the physical antibacterial surfaces on Ti-based biomaterials were also summarized.

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引用本文

张哲,刘慧,林漫峰,蔡宗原,赵大鹏.钛基植入材料的物理抗菌表面修饰[J].稀有金属材料与工程,2025,54(1):84~93.[Zhang Zhe, Liu Hui, Lin Manfeng, Cai Zongyuan, Zhao Dapeng. Physical Antibacterial Surface Modifications on Titanium-Based Implant Materials[J]. Rare Metal Materials and Engineering,2025,54(1):84~93.]
DOI:10.12442/j. issn.1002-185X.20240527

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  • 收稿日期:2024-08-15
  • 最后修改日期:2024-11-29
  • 录用日期:2024-10-15
  • 在线发布日期: 2025-01-24
  • 出版日期: 2025-01-20