High-temperature thermo-mechanical experiments were conducted to investigate the behavior of self-developed new type zirconium cladding under loss-of-coolant accident (LOCA) conditions, including high-temperature oxidation, high-temperature creep, high-temperature burst, and embrittlement experiment. Results show that the high-temperature oxidation rate of self-developed new type zirconium cladding is comparable to that of ZIRLO, M5, and Zr-4 cladding when the oxidation temperature exceeds 1000 °C, which can be estimated by Cathcart-Pawel model. Notably, the self-developed new type zirconium cladding exhibits significantly lower high-temperature creep-burst strain than M5 and Zr-4 cladding, which can decrease fuel assembly blockage during LOCA, thus contributing to a more favorable outcome in LOCA analysis. Additionally, the embrittlement criteria of the self-developed new type zirconium cladding meet the requirements of a peak cladding temperature of ≤1204 ℃ and the maximum cladding oxidation rate of ≤17%.