Mo–Cu functionally graded material was fabricated by a method which combines combustion synthesis with centrifugal infiltration. During the process, Cu melt produced by combustion reaction was infiltrated into a homogeneous Mo powder bed under high gravity. The as-prepared sample showed gradually-varying properties in terms of relative density, thermal diffusion coefficient and hardness. The content of heavy Mo phase decreases gradually from 75 to 40 vol.% along high gravity direction. The relative density of Mo–Cu FGM decreases from 97.6 to 96.5%, which can be attributed primarily to the increase in shrinkage cavity along high gravity direction. The thermal diffusion coefficient of Mo–Cu FGM increases from 43.2 to 66.6 mm₂ s_-1 due to the increase in Cu content along high gravity direction. The hardness of Mo–Cu FGM decreases gradually from 1390 to 710 MPa, as the content of Cu and porosity increases along high gravity direction.