Graded Ti-6Al-4V reticulated meshes with different porosities in Materialise software were fabricated by additive manufacturing using the electron beam melting (AM-EBM) and the effects of annealing temperature on the microstructure and mechanical properties of these samples were studied. The results show that the strut microstructure is dominated by thinα’martensiteplatelets and minimal β phase. The effective modulus and strength are theweighted average of the moduli and strengthof each constituent. There is stressdiscontinuity along the interface between thetwo different layers,which causesthe reduction of strength. Annealed in the temperature of 950_oC for 1 h, α platelets are thickerand the plastic of struts is improved, at the same time, the effective elastic modulus and compressive strength are slightly reduced. After annealing treatment, the graded Ti-6Al-4V meshes achieve the optimal mechanical performance.