In order to enlarge the dimensions of titanium cladding steel plate, a new method of two main procedures was used, in which the DT4 thin slice was exploded firstly with titanium plate to assemble billet according to a symmetrical way. The effects of rolling and annealing temperatures on the shear strength of titanium cladding steel plate were investigated. The microstructures and interfacial diffusion of the cladding plates were observed or measured by optical microscope, scanning electric microscope and micro-hardness tester. The results show that the shear strength of the cladding plates is remarkably depended on the rolling and annealing temperatures, and the brittle compound amount in the interface of titanium/DT4 will increase evidently and the shear strength of titanium cladding steel plate will decrease sharply when the rolling temperature is above 882 ℃ (the α→β phase transformation temperature of titanium), or the annealing temperature is above 750 ℃. The micro-hardness peak value appears in titanium side when the annealing temperature is higher than 900 ℃ due to Fe element diffusion in titanium. Annealed within the range from 550 to 650 ℃, the shear strength will slightly increase.