The thermal stability of Zr50Ti5Cu18Ni17Al10 bulk metallic glass was studied by differential scanning calorimeter (DSC) in the mode of continuous heating. The activation energies of glass transition (Eg) and crystallization (Ep1 and Ep2) are 438±11, 284±8 and 323±11 kJ/mol, respectively. The study of mechanical properties was conducted in compression at room temperature under an initial strain rate of 1×10?4 s?1. The metallic glass rods with a diameter of 3 mm exhibit a good mechanical property. The plastic strain prior to fracture is up to 3%, and the maximum values of Young’s modulus and ultimate fracture strength are 90 GPa and 1968 MPa, respectively. The intersecting, branching and sliding of multiple shear bands and the larger critical shear offset with a width of 60 mm are the major reason for the higher compressive plasticity in the Zr50Ti5Cu18Ni17Al10 bulk metallic glass.