By means of the technology of split Hopkinson bar, dynamic compression experimentation on TC6 titanium alloy have been carried out for cylindrical specimens cut along different directions of deformed contexture. The susceptibility of the different directions of deformed contexture of the TC6 titanium alloy to adiabatic shearing has been studied by means of associating their mechanical response under high strain rate with micro-analysis. Results show that the sensitivities of the different directions to adiabatic shearing are highly anisotropy. RD has the lowest sensitivity to adiabatic shearing and ND has the highest to adiabatic shearing. The differences of susceptibility of the different directions of deformed contexture to adiabatic shearing are caused by different thermal softening effect in the course of dynamic deformation