By using monotonic tension and fully-reversed tension-compression loading with strain control (R = emin/emax= –1), the tensile properties and low cycle fatigue (LCF) behavior of NZ2 alloy plate were studied with different hot-rolling temperatures (650, 700 and 800 oC), different orientation (rectangular and transverse) and different testing temperatures (room temperature and 375 oC). Results indicate that NZ2 alloy plates with lower hot-rolling temperature (650 oC) have better comprehensive mechanical properties by analyzing the microstructure, mechanical properties and the low cycle fatigue lifetime curves