Abstract： The some parameters of preparation ethanolamine hydroxyl platinum(Ⅳ), such as concentration of platinum, the amount of oxidant and sodium hydroxide, was tested by means of single factors experiment design, and optimized by response surface method. and then established an empirical mathematical model for to predict yield of ethanolamine hydroxyl platinum(Ⅳ). The results demonstrated that the significance of influence factor as followed the order, platinum concentration＞oxidant amount＞NaOH amount. The yield(89.625%)of ethanolamine hydroxyl platinum(Ⅳ) could be obtained under the optimized conditions, platinum concentration 100g.L-1, oxidant amount 10%, and NaOH amount 2.25 times(in mass). The results show that the empirical mathematical model was feasible for the optimized parameters to prepare ethanolamine hydroxyl platinum(Ⅳ) and also to predict its yield. The structural formula of the compounds was verified of (NH3CH2CH2OH)2Pt(OH)6 by the sample characterization.