Because of their excellent low temperature comprehensive properties, titanium alloys have gradually attracted considerable attention as important engineering materials at low temperatures. The application situation of titanium alloys at cryogenic temperatures in recent years is critically reviewed. The recent progress of deformation mechanisms of titanium alloys at low temperatures, including alpha titanium alloys, alpha/ beta double phases and beta titanium alloys, is then overviewed and concluded. Different influences of temperatures, alloy composition, deformation factors and microstructure on plastic deformation mechanisms of titanium alloys at cryogenic temperatures are summarized. Finally, the development trend of titanium alloys used at cryogenic temperatures is also discussed, in order to provide some valuable references to design and explore new titanium alloys with better comprehensive performance at cryogenic temperatures.