A composite coating was prepared to control drug release and corrosion of magnesium alloys stent materials AZ81, and the corrosion resistance, drug release and biocompatibility were investigated. IR spectrum and DSC results show that paclitaxel can be evenly dispersed in the PLGA. The drug-release curves indicate that the cumulative release rate after 30 d reaches approximately 80%. SEM, the electrochemical impedance spectroscopy, polarization curve and magnesium release results suggest that the PLLA coating improve the corrosion resistance by preventing the corrosive ions from diffusing to the magnesium substrate. The blood and cell test results reveal that the samples have good hemocompatibility and no cytotoxicity