Six kinds of Ti-6Al-4V artificial bone scaffold were designed and built with SLM (Selective Laser Melting) technology. Universal material testing machine and high-speed camera were used to analyze the compression process of scaffolds, and ANSYS was used to analyze the stress of scaffold. The results showed that the vertical column diameter had a great influence on the mechanical property parameters of scaffolds but the beam diameter had little influence on them, under the same height, the increasing of beam diameter and layer or support column diameter, which result in structure length-diameter ratio decrease, so that structure firm and load-carrying capacity were improved and the mechanical property should match the surrounding bone tissue. Through the analysis, mechanical property parameters of three kinds of scaffolds were close to human femur, so they can be used as the artificial bone scaffolds of femur.