The aim of the research is to study the effects of casting tungsten carbide powder on wear resistance of ceramic particle reinforced Fe matrix composites by laser cladding. The tungsten carbide powders with different particle size preapred by different methods were added into Fe alloy powders. The laser cladding technique was used to form alloyed layer with high hardness and wear resistance on 45# steel with such mixed powders. The microscope, SEM, XRD and hardness tester were used to investigate microstructure, phase composition and microhardness of cladding layer. The wheel wear test machine was used to test their wear resistance. The result shows the cladding layer is mainly composed of ledeburite phase. The difference of tungsten carbide powder makes important effects on wear resistance. The tungsten carbide powder prapared by plasma rotating electrode process can increase wear resistance mostly. The increasing effect of fine tungsten carbide powder on wear resistance is more remarkable than the coarse powder.