The Zr70Al8Cu22-xNix（x=8.5,9,9.5,10,10.5,11）bulk amorphous alloy rods with 2mm diameters were prepared by copper mold casting technique,and the effect of Ni/Cu content ratio on thermal stability and mechanical properties of Zr-based amorphous alloys were investigated by differential scanning calorimeter（DSC）and uniaxial compression test methods.The results show that the value of supercooled liquid regionΔTx change from 80K to 81Kwith the Ni/Cu content ratio increase,but theΔTx have a bigger value than other alloys when Ni/Cu content ratio arrive 0.63 and 0.76,when Ni/Cu content ratio arrive 0.76,which has a better thermal stability because of itsΔTx value is 89K.And the plastic strain exhabit a downward tend with the Ni/Cu content ratio increase,but there exists a unnormal larger value when Ni/Cu content ratio arrive 0.76,which has good plastic strain,and the compressive strength has a downward tend over all with wave and changeless nature.And the young modulus value arrives the maximum value 80 GPa when Ni/Cu content ratio is 0.63,but other alloys change from 58 GPa to 65 GPa.In totally, the plastic strain,compressive strength and young modulus also arrive the maximum value when Ni/Cu content ratio is 0.63.