Cu/Ti3SiC2/C/MWCNTs/Graphene/La nanocomposites were fabricated by vacuum hot-pressing sintering and hot isostatic pressing. Effect of lanthanum (La) content on tribological behavior of Cu/Ti3SiC2/C/MWCNTs/Graphene/La nanocomposites against GCr15 was evaluated using a wear and abrasion tester. Effect of La content, normal force and rotational speed on tribological behavior of the nanocomposite was investigated to analyze their interaction mechanism. The mutual influence of La content, normal force and rotational speed was analyzed by orthogonality analysis, variance analysis and range analysis. The morphologies of worn surfaces have been observed and analyzed by means of scanning electron microscope (SEM) and energy dispersive x-ray spectroscopy (EDS). Results demonstrate that La content plays a primary role in the influence of friction and wear performance results. The wear mechanism of nanocomposites with 0.05 wt.% La is abrasive wear, delamination wear and oxidation wear. And wear mechanism of nanocomposites with 0.1 wt.% and 0.3 wt.% La is adhesive wear and oxidation wear.