Nanoindentation and Vikers indentation tests were carried out to characterize the hardness and elastic modulus profiles in the vicinity of welding area for TC11/Ti2AlNb alloys with different conditions. Distribution of nano/micro scales mechanical behavior was analyzed combined with the microstructure. It was shown that the decomposed martensite α" phase was the major contributor to the reduction of hardness in the heat affected zone of TC11 alloy. Phases precipitated in welding zone and heat affected zone of Ti2AlNb alloy resulted in the hardness increased. Forging and heat treatment processes can improve the elastic modulus of the welding area. After welding, the elastic modulus was only ~92GPa in the welding zone, but the value was risen up to ~130GPa after heat treatment. Meanwhile, the yield strength of the welding zone increased after deformation treatment, which was consistent with the results that the hardness and elastic modulus variation in the welding area.