A new sandwich core called lotus seedpod-like core is proposed in this paper. High temperature creep forming experiment was conducted on TC4 titanium plate to prove the feasibility of lotus seedpod-like core. Moreover, effects of major forming parameters on the height, microstructure, mechanical properties of the lotus seedpod-like core were studied. The results show that it is feasible to prepare lotus seedpod-like core by high temperature creep forming. During creep forming, TC4 titanium sheet transformed to lotus seedpod-like core by dislocation motion and grain boundary sliding. After high temperature creep, the fine equiaxed structure completely transformed into the recrystallized equiaxed structure. The height, compressive strength and specific compressive strength of core are increased with the increase of forming pressure and holding time.