高芮宁,熊胤泽,张航,董兰兰,李剑涛,李祥.SLM制备径向梯度多孔钛/钽及其表征研究[J].稀有金属材料与工程,2021,50(1):249~254.[Gao Ruining,Xiong Yinze,Zhang Hang,Dong Lanlan,Li Jiantao,Li Xiang.Fabrication and characterization of radially graded porous titanium/tantalum via selective laser melting[J].Rare Metal Materials and Engineering,2021,50(1):249~254.]
SLM制备径向梯度多孔钛/钽及其表征研究
投稿时间:2019-12-31  修订日期:2020-02-19
中文关键词:  三周期极小曲面  径向梯度多孔钛/钽  激光选区熔化  力学性能  生物相容性
基金项目:国家自然科学基金(项目号51475293),上海交通大学医工交叉基金面上项目(项目号YG2017MS60),上海交通大学医工交叉研究基金(项目号YG2017MS79)
中文摘要:
      利用增材制造技术制作仿天然骨的径向梯度多孔钛/钽骨科植入物具有广阔的前景。基于三周期极小曲面(triply minimal surfaces,TPMS)建模法建立了平均孔隙率为70%的圆柱型径向梯度孔隙结构,孔隙率由中轴线(90%)向圆周面(30%)逐渐降低。利用激光选区熔化(Selected Laser Melting, SLM)工艺制作径向梯度多孔钛/钽。光学显微镜,扫描电镜,Micro-CT检测结果共同显示,SLM径向梯度多孔钛/钽的孔隙结构与设计特征一致。SLM工艺制作的径向梯度多孔钛/钽的孔隙率分别为73.18%与68.18%。力学测试结果表明,梯度多孔钛/钽的弹性模量分别为3.96±0.19GPa与3.47±0.25GPa,抗压强度分别为90.83±3.35MPa与93.27±1.24MPa。梯度多孔钛/钽的弹性模量与抗压强度分别显著高于均匀多孔钛/钽(孔隙率为70.11%的均匀多孔钛弹性模量为2.34±0.48GPa,抗压强度为67.63±1.33MPa,孔隙率为65.39%的均匀多孔钽弹性模量为1.69±0.49GPa,抗压强度为68.56±0.41MPa)。体外细胞相容性实验证明,径向梯度多孔钛/钽均具有良好的生物相容性,适合间充质干细胞与肌肉细胞的粘附生长。SLM工艺制作的径向梯度多孔钛/钽比均匀多孔钛/钽具有与天然骨组织更相近的结构与性能,是理想的骨缺损修复替代物。
Fabrication and characterization of radially graded porous titanium/tantalum via selective laser melting
英文关键词:triply minimal surfaces, radially graded porous titanium/tantalum, selective laser melting, mechanical properties, biocompatibility
英文摘要:
      Radially graded porous titanium / tantalum orthopedic implants fabricated by additive manufacturing technology have golden prospects. A cylindrical radially graded porous scaffold with an average porosity of 70% was built by using the triply minimal surfaces (TPMS) modeling methods, and the porosity gradually decreases from the central axis (90%) to the circumferential surface (30%). Selected laser melting (SLM) process was used to fabricate this scaffold. Optical microscopy, scanning electron microscopy, and Micro-CT results show that the SLM titanium/tantalum were consistent with the design models. The porosities of the SLM radially graded porous titanium / tantalum are 73.18% and 68.18% respectively. The mechanical test results show that the elastic modulus of radially graded porous titanium / tantalum are 3.96 ± 0.19GPa and 3.47 ± 0.25GPa respectively, and the compressive strength are 90.83 ± 3.35MPa, 93.27 ± 1.24MPa respectively. Both of them are significantly higher than those of homogeneous porous titanium / tantalum respectively. (Homogeneous porous titanium with an average porosity of 70.11% has an elastic modulus of 2.34 ± 0.48GPa and a compressive strength of 67.63 ± 1.33MPa; Homogeneous porous tantalum with a porosity of 65.39% has an elastic modulus of 1.69 ± 0.49GPa and a compressive strength of 68.56 ± 0.41MPa). In vitro cytocompatibility experiments show that both radially graded porous titanium and tantalum have good biocompatibility and they are suitable for the adherent and growth of mesenchymal stem cells and muscle cells. The radially graded porous titanium / tantalum fabricated by the SLM process has more similar structure and properties to natural bone tissue than homogeneous porous titanium / tantalum, and both of them are an ideal substitute for bone defect repair.
作者单位E-mail
高芮宁 上海交通大学机械与动力工程学院 gaoruining@sjtu.edu.cn 
熊胤泽 上海交通大学机械与动力工程学院  
张航 上海交通大学机械与动力工程学院  
董兰兰 上海交通大学机械与动力工程学院  
李剑涛 上海交通大学附属胸科医院肺部肿瘤临床医学中心  
李祥 上海交通大学机械与动力工程学院 xiangliwj@sjtu.edu.cn 
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