To investigate the effect of γ′ morphology and secondary phase on the plastic deformation behavior of co-8.8al-9.8w alloy were prepared,Mo was added to prepare the alloy with different morphology of γ′ phase and secondary phase. The microstructure and room temperature compression behavior of the alloy were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results showed that the compressive strength and plastic deformation ability of the two alloys are almost the same, but the hardness of the 0Mo alloy with cubic γ′ phase is significantly higher than that of the 2Mo alloy with spherical γ′ phase; The fracture mechanism of 0Mo alloy during compression is cleavage fracture, but 2Mo alloy is quasi-cleavage fracture; The spherical γ′ phase rafted under the action of stress, and segregated along the deformation direction, however the morphology and distribution of the cubic γ′ phase did not change significantly; The W-rich secondary phase distributed in the 2Mo alloy will hinder the movement of dislocations.