Detonation experiments were carried out with three precursor gases (CH4-2O2、H2-0.5O2 、C2H2-2.5O2). The detonation characteristics of premixed gas were characterized by the measured detonation pressure, velocity and cell size. Based on the measured detonation parameters, a detonation duct with length of 2m, inner diameter of 80mm, wall thickness of 8mm and ignition energy of 40J is designed independently. Nano titanium dioxide was synthesized by gas-liquid detonation with hydrogen, oxygen and titanium tetrachloride as mixed precursors in the independently designed detonation duct. The products were characterized by TEM. The results show that the spherical or quasi spherical particles of the obtained nano titanium dioxide are about 20-150 nm.