With the rapid development of the catalysis field, the demand for platinum group metal nanomaterials is also increasing. So it is of great significance to provide a new method for preparing platinum group metal and alloy powders that is simple, efficient, easy to industrialization and universal. In this paper, Pd, Pt, Ir and Ru powders and IrRu, PtNi and PtNiCo alloy powders with 3D-nanoframeworks structure were successfully prepared by spray drying method combined with calcination and reduction using noble metal salt as raw material and ammonium chloride (NH₄Cl) as pore making agent. The effect of NH₄Cl concentration on the micromorphology of atomized powder was studied. It was found that with the increase of NH₄Cl concentration, the average particle size of atomized (NH₄)₂PdCl₄ powder showed an increasing trend, the sphericity gradually decreased, and the dispersion became worse. The effects of different calcination temperatures on the morphology of palladium powder were studied, and it was found that palladium powder reduced by calcination at 300℃ had an inherited effect on the precursor shape. Due to the nano-pores left by the gas spilling during calcination, palladium powder had a spheroidal 3D-nanoframeworks structure and a large specific surface area (28-40 m₂^/g). When the calcination temperature rises to 400℃, the 3D-nanoframeworks is gradually broken to form a dense Pd powders. Therefore, when the concentration of NH₄Cl is 5-10 g/L and the calcination temperature is controlled at 300℃, it is conducive to the preparation of spherical 3D-nanoframeworks platinum group metal powders with high specific surface area. In addition, Pt, Ir, Ru, IrRu, PtNi and PtNiCo platinum group metals and alloy powders with 3D-nanoframeworks have been successfully prepared by using the optimal preparation parameters, which proves that the method is universal in the preparation of other platinum group metals and alloys. Finally, in order to prove the feasibility of the synthetic materials, the catalytic methanol oxidation reaction of the PtNiCo 3D-nanoframeworks materials prepared in this study was tested in fuel cell anode. The results showed that the catalytic methanol oxidation performance of PtNiCo nanomaterials (1117 mA/mg_Pt) was 6.5 times that of commercial Pt black (170 mA/mg_Pt), and it also has Excellent anti-toxicity and stability. It was proved that excellent performance of platinum group metal alloy nano-catalyst could be prepared by the preparation method in this study.