GH4169 alloy samples with different TC4 content were prepared via ball milling alloying and laser melting deposition by adding TC4 alloy powder to conventional GH4169 alloy powder instead of Al and Ti alloying. The effects of TC4 addition on microstructure and properties of GH4169 alloy prepared by laser melting deposition were investigated. The results show that TC4/GH4169 alloy is mainly composed of coarse columnar crystals, but the primary dendrite arm spacings and grain size of the columnar crystals decrease. Besides, the Laves phase changed from continuous long chain to diffuse short rod with the aspect ratio decreased from 9.2 to 2.6. During the deposition process, TC4 melted with Ti and Al elements releasing. The released elements were fully dissolved into GH4169 alloy melt and participated in solidification and microstructure formation of the alloy, subsequently. The addition of TC4 increased the solidification rate of the alloy deposition pool and reduced the segregation of elements in the solidification structure. Besides, the addition of TC4 promoted precipitation of γ? and γ? in the solidification microstructure. Thus, the hardness and mechanical properties of the deposited alloy were improved. The addition of TC4 shows effects of fine crystal strengthening, solid solution strengthening and precipitation strengthening.